Antibiotics from Microbes – Invisible Defences:<\/p>\n
DBT LAUNCHES MISSION PROGRAMME ON SCREENING FOR BIO-MOLECULES FROM MICROBIAL DIVERSITY COLLECTED FROM DIFFERENT ECOLOGICAL NICHES<\/p>\n","protected":false},"excerpt":{"rendered":"
Demand for new and more effective antibiotics continues to grow particularly as bacterial resistance to existing antibiotics spreads. The market for antibiotic drugs is huge. In 2005, worldwide sales of oral antibiotics totaled USD 25 Billion including US sales of $8.5 billion ($7.0 billion for adults and $1.5 billion for children). Apart from being huge, the market is also growing at a significant rate, with adult and pediatric prescriptions growing in 2005 at 8.5% and 10.8% respectively.<\/p>\n
Department of Biotechnology has recently initiated a network project called \u201cScreening for Bio-molecules from microbial diversity collected from different ecological niches\u201d. The project involves nine institutes, with NPIL Research & Development Limited (NRDL) as an industrial partner. The total cost of the project is Rs.24.86 crores with DBT contribution of Rs.17.98 Crores. Rs. 6.88 Crores is being contributed by NRDL. The participating institutes are:-<\/p>\n
\u00d8 National Environmental Engineering Research Institute (NEERI), Nagpur<\/p>\n
\u00d8 National Centre for Cell Science (NCCS), Pune<\/p>\n
\u00d8 Institute of Genomics and Integrative Biology (IGIB), Delhi<\/p>\n
\u00d8 University of Delhi, South Campus (UDSC), Delhi<\/p>\n
\u00d8 Institute of Life Sciences (ILS), Bhubaneswar<\/p>\n
\u00d8 M. S. Swaminathan Research Foundation (MSSRF), Chennai<\/p>\n
\u00d8 Guru Nanak Dev University (GNDU), Amritsar<\/p>\n
\u00d8 Institute of Bioresources and Sustainable Development (IBSD), Imphal<\/p>\n
\u00d8 National Institute of Oceanography (NIO), Panjim<\/p>\n
The project envisages a mega scale screening programme for various environmental isolates. This is the first project in the country where industry and academia will work together to screen such a large number of bacterial isolates. Different academic institutes will isolate organisms specific to diverse ecological niches. For each sample, isolation of bacteria will be carried out on 30 different growth media.<\/p>\n
This multi-institutional effort will generate approximately 7000 isolates\/month (~1000\/institute), which will be regularly sent to NRDL, the industrial partner of the project. Screening will be carried out for anti-cancer, anti-infective, anti-diabetes and anti-inflammation properties. In addition to culture dependent method, the culture independent approach will also be taken up for a few selected samples.<\/p>\n
The project will lead to selection of potential candidate molecules, which will be taken to process scale-up strategies with appropriate partners. The credit sharing in this project amongst the PI and industry has been mutually worked out and an agreement has been signed on 22nd February 2008 in the presence of Union Minister for Science & Technology and Earth Sciences, Shri Kapil Sibal.<\/p>\n
A separate Microbial Repository is being set up at National Centre for Cell Science (NCCS), Pune to maintain the 2,00,000 isolates generated under this project. This would be the largest such facility in the country and would confirm to International Depository Authority (IDA) standards.
\nPIB\/PRA\/SKK<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-247","post","type-post","status-publish","format-standard","hentry","category-health-fitness"],"_links":{"self":[{"href":"https:\/\/citynews.co.in\/index.php?rest_route=\/wp\/v2\/posts\/247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citynews.co.in\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citynews.co.in\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citynews.co.in\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citynews.co.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=247"}],"version-history":[{"count":0,"href":"https:\/\/citynews.co.in\/index.php?rest_route=\/wp\/v2\/posts\/247\/revisions"}],"wp:attachment":[{"href":"https:\/\/citynews.co.in\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citynews.co.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citynews.co.in\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}